More Exercise = More Plaque – Why?

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Initial Analysis/Video: https://www.youtube.com/watch?v=Cg5kZxc0tls&t=96s

0:00 – Introduction
0:59 – Occult Blood Pressure
5:50 – A Break in the Science: 10 Crazy People
10:16 – 2 Critiques: Nutrition, Calcified Plaque
13:39 – Exercise is Harmful Now? Please Watch.

References
*Full Funding/Conflicts are provided in the free article (found in email list and Physionic Community Article Library)
[Study 699] Pauwels R, Dausin C, Ruiz-Carmona S, De Bosscher R, De Paepe J, Bekhuis Y, et al. Wearable-derived training load and coronary atherosclerosis in middle-aged and older athletes and physically active controls: a new perspective from the Master@Heart Study. Circulation. Published online January 29, 2026. doi:10.1161/CIRCULATIONAHA.125.077117.

[Study 703] De Bosscher R, Dausin C, Claus P, et al. Lifelong endurance exercise and its relation with coronary atherosclerosis. European Heart Journal. 2023;44(26):2388–2399. doi:10.1093/eurheartj/ehad152.

[Study 973] O’Driscoll J, Parry-Williams G, Moser J, et al. Resting and exercise-induced occult hypertension and coronary atherosclerosis in male masters endurance athletes. British Journal of Sports Medicine. Published online April 24, 2026. doi:10.1136/bjsports-2025-111347.

[Study 975] Grandys M, Majerczak J, Frolow M, Chlopicki S, Zoladz JA. Training-induced impairment of endothelial function in track and field female athletes. Scientific Reports. 2023;13(1):3502. doi:10.1038/s41598-023-30165-2.

[Study 976] Lin J, DeLuca JR, Lu MT, et al. Extreme endurance exercise and progressive coronary artery disease. Journal of the American College of Cardiology. 2017;70(2):293–295. doi:10.1016/j.jacc.2017.05.016.

[Study 977] Bretherton KN, Day AJ, Skinner SL. Effect of hypertension on the entry of ¹²⁵I-labelled low-density lipoprotein into the aortic intima in normal-fed rabbits. Atherosclerosis. 1976;24:99–106.

[Study 979] Liu ML, Bergholm R, Mäkimattila S, et al. A marathon run increases the susceptibility of LDL to oxidation in vitro and modifies plasma antioxidants. American Journal of Physiology-Endocrinology and Metabolism. 1999;276(6):E1083–E1091. doi:10.1152/ajpendo.1999.276.6.E1083.

[1] Sánchez-Quesada JL, Ortega H, Payés-Romero A, et al. LDL from aerobically trained subjects shows higher resistance to oxidative modification than LDL from sedentary subjects. Atherosclerosis. 1997;132(2):207–213. doi:10.1016/S0021-9150(97)00108-1.

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